Research

The mission of the Dorrity lab is to understand the molecular and cellular sources of robustness in development.

We pursue this with tools from single cell genomics, protein science, and computational biology, combining insights from multiple species.

Temperature

  • Cell types

    Genetic modifiers of cell type-specific temperature sensitivity

  • Tools

    Genetic tools for controlling cellular temperature response

  • Sensing

    Understanding species-specific temperature sensing at the protein level

  • Growth

    Environmental control of reproductive growth trajectories

    (with Vu Lab)

Developmental timing

  • Cross-species

    Comparing developmental trajectories across fish species

  • Stage-specific

    Detecting lineage-specific acceleration and delay

  • Trajectories

    Aligning developmental progression across species

  • Engineering

    Driving cell type-specific developmental acceleration

Evolution

  • Natural variation

    Whole-animal cellular profiling in natural populations

    (with Arendt Lab)

  • Protein homeostasis

    Evolution of cell type-specific stress response during development

  • Cell composition

    Comparative analysis of cellular profiles in fish using sci-RNA-seq.